Algorithms for improved Identification of Mutations
For discovery of tumor mutations using next-generation sequencing to guide vaccine selection and design, a novel statistical method will be tested and analyses will be optimized.
Compounds to enhance Vaccine Efficacy
Preclinical research will address testing of improved formulations of the RNA vaccines, testing of RNA encoded adjuvants as combination therapies and the combination with immune-modulating agents that are approved or in clinical testing.
Trial accompanying Biomarker Program
The clinical trial will be accompanied by an extensive clinical biomarker program to study the immunity and the prognostic or predictive value of markers for immunogenic cell death.